Tetraphenylporphyrin derivative specifically blocks members of the voltage-gated potassium channel subfamily Kv1
نویسندگان
چکیده
منابع مشابه
The voltage-gated potassium channel subfamily KQT member 4 (KCNQ4) displays parallel evolution in echolocating bats.
Bats are the only mammals that use highly developed laryngeal echolocation, a sensory mechanism based on the ability to emit laryngeal sounds and interpret the returning echoes to identify objects. Although this capability allows bats to orientate and hunt in complete darkness, endowing them with great survival advantages, the genetic bases underlying the evolution of bat echolocation are still...
متن کاملExpression and differential distribution of the shaker-related voltage-gated potassium channel family (KV1.x) in human hippocampus and neocortex
Background All excitable cells express voltage-gated potassium (KV) channels; in neurons they play an essential role in setting the resting membrane potential, controlling the firing frequency and duration of action potentials, and modulate neurotransmitter release. Due to this critical function as regulators of neuronal excitability, mutations and/or deletions in potassium channel subunit gene...
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The present research article relates to the discovery of the novel drugs based on Zonisamide to treatment of autism disease. In first step, the electronic properties, reactivity and stability of the said compound are discussed. To attain these properties, the said molecular structure is optimized using B3LYP/6-311++G(d,p) level of theory at room temperature. The frontier molecular orbitals (FMO...
متن کاملThe isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel
Domains in macromolecular complexes are often considered structurally and functionally conserved while energetically coupled to each other. In the modular voltage-gated ion channels the central ion-conducting pore is surrounded by four voltage sensing domains (VSDs). Here, the energetic coupling is mediated by interactions between the S4-S5 linker, covalently linking the domains, and the proxim...
متن کاملA voltage-gated ion channel expressed specifically in spermatozoa.
Calcium ions play a primary role in the regulation of sperm cell behavior. We report finding a voltage-gated ion channel (CatSper2) that is expressed in male germ cells but not in other cells. The putative channel contains 6 transmembrane segments, making it more similar to the voltage-gated potassium channels, but the ion selectivity pore domain sequence resembles that of a Ca(v) channel. The ...
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ژورنال
عنوان ژورنال: Channels
سال: 2013
ISSN: 1933-6950,1933-6969
DOI: 10.4161/chan.25848